Evolocumab
RepathaUniProt Q8NBP7 · 3D model
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A lab-made antibody that blocks PCSK9, a protein that normally limits how much “bad” cholesterol the liver clears — blocking it lowers cholesterol further.
How it works
Normally, the liver has docking stations (LDL receptors) on its surface that grab bad cholesterol out of the blood. A protein called PCSK9 interferes with this by marking those docking stations for destruction. Evolocumab is an injectable antibody that latches onto PCSK9 and neutralizes it, so the liver keeps more of its docking stations and pulls more LDL cholesterol out of circulation.
What it’s used for
Used to lower bad cholesterol and cut the risk of heart attack, stroke, and procedures to reopen blocked arteries in adults who already have heart disease. Also used for general high cholesterol and for inherited forms of very high cholesterol in adults and children as young as 10.
- Mechanism
- PCSK9 inhibitor (mAb)
- Drug class
- Monoclonal antibody
- Therapeutic area
- Cardiovascular