Lisinopril and hydrochlorothiazide

Zestoretic

Mechanism of action: ACE inhibitor + thiazide diuretic (fixed-dose combination)
In plain language: Combines two blood pressure medicines in one tablet: lisinopril, which relaxes blood vessels by blocking a hormone that narrows them, and hydrochlorothiazide, a diuretic that helps the kidneys remove extra salt and water from the blood.
How it works: ZESTORETIC combines lisinopril, an ACE inhibitor, and hydrochlorothiazide, a thiazide diuretic. Per the FDA label, lisinopril inhibits angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II, a potent vasoconstrictor that also stimulates aldosterone secretion; the result is decreased vasopressor activity and lower blood pressure. Hydrochlorothiazide acts on a separate part of the kidney's distal tubule, increasing excretion of sodium and chloride (and with it, water) to reduce blood volume. The two mechanisms are complementary, and the diuretic component can offset the modest potassium retention lisinopril alone can cause.
Therapeutic applications: ZESTORETIC is FDA-indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
Class: Fixed-dose combination
Therapeutic area: Cardiovascular
Source: FDA label (DailyMed) ↗

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