Synjardy
Empagliflozin and metformin hydrochlorideDrag to rotate. Scroll or pinch to zoom.
Combines two diabetes medicines in one tablet: empagliflozin, which makes the kidneys pass extra sugar out in the urine, and metformin, which tells the liver to release less sugar into the blood and helps the body use insulin more effectively.
How it works
Synjardy puts two diabetes medicines into one tablet, and they work in different places in the body. Empagliflozin acts on the kidneys, telling them to let extra sugar pass out in the urine instead of being reabsorbed back into the blood. Metformin works on the liver and muscles instead, telling the liver to release less sugar into the blood and helping the body use insulin more effectively. Because the two act on different systems, combining them controls blood sugar better than either alone.
What it’s used for
Synjardy is prescribed, alongside diet and exercise, to help adults and children 10 and older with type 2 diabetes manage their blood sugar using two medicines in one pill instead of two separate prescriptions. Because it contains metformin, it carries a boxed warning — the FDA's strongest safety warning — about a rare but serious condition called lactic acidosis.
- Mechanism
- SGLT2 inhibitor + biguanide (fixed-dose combination)
- Drug class
- Fixed-dose combination
- Therapeutic area
- Metabolic / Diabetes