Romiplostim
NplateUniProt P40225 · 3D model
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A lab-made molecule that mimics the hormone thrombopoietin, signaling the body to make more platelets.
How it works
Platelets are blood cells that help stop bleeding, and they're normally made in the bone marrow under instructions from a hormone called thrombopoietin. Romiplostim is engineered to act like that hormone, attaching to the same receiver on marrow cells even though it's built differently at the molecular level. This tells the bone marrow to ramp up production of the cells that become platelets.
What it’s used for
Used to raise dangerously low platelet counts in adults and children with chronic immune thrombocytopenia when other treatments haven't worked well enough. Also used in people exposed to a harmful dose of radiation, to help their bone marrow recover.
- Mechanism
- Thrombopoietin receptor agonist (Fc-peptide fusion)
- Drug class
- Fusion protein
- Therapeutic area
- Hematology