Fluconazole

Fluconazole blocks an enzyme that fungi need to make ergosterol, a substance that keeps their cell membrane strong and stable. Without enough ergosterol, the fungal cell membrane becomes weak and leaky, which stops the fungus from multiplying. Human cells rely on a similar enzyme, but fluconazole is much less likely to affect it, so the drug targets fungi while largely sparing our own cells. Some fungi can eventually develop resistance by altering or pumping out the drug, which is why the correct dose and length of treatment matter.